CSF

Neuronal Pentraxin 2 - A Synapse-Derived CSF Biomarker in Genetic Frontotemporal Dementia

We conclude that NPTX2 is a promising synapse-derived disease progression biomarker in genetic FTD.

Addition of the Aβ42/40 Ratio to the Cerebrospinal Fluid Biomarker Profile Increases the Predictive Value for Underlying Alzheimer's Disease Dementia in Mild Cognitive Impairment

Our results confirm the usefulness of the CSF Aβ42/40 ratio in the interpretation of CSF biomarker profiles in MCI patients, by increasing the proportion of conclusive profiles and enhancing their predictive value for underlying AD.

Association Between Butyrylcholinesterase and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease Patients

In our population, the BuChE-K variant does not seem to confer risk for AD or to influence the activity of the enzyme in CSF. However, we demonstrated an association between BuChE activity, ApoE-ε4 genotype and CSF Aβ42 levels, highlighting the importance of assessing BuChE activity as a possible modulator of Aβ load in the brain.